Connection supplements vary in intensity of connection and duration of effect.
Regarding intensity and duration, LSD has high intensity and long duration, while cannabis has lower intensity and lower duration. Note that there is a considerable difference in duration between cannabis that is inhaled and cannabis that is ingested. When inhaled, duration is typically 90 minutes. When ingested, duration is approximately six hours.
In general, guidance from experienced and authentic new energy guides is recommended, especially when attempting connection with more intense substances.
To achieve successful, grounded, aligned, non-paranoid, fear-less connection, it is important to establish Aligned Thought, Aligned Environment, and Aligned Action. Lightning Path materials, and in particular the Triumph of Spirit Archetype System, are designed to help facilitate alignment. To get started on the Lightning Path, visit https://www.lightningpath.org/
Neurology is not well understood at this time, but it appears that connection is facilitated via suppression of the Default Mode Network (Sosteric, SOA) and activation of unused neural pathways.
In regards to cannabis, the cannabinoid receptors (CB1) are located throughout the body, in the brain, liver, lungs fat cells, uterus, and sperm!. When either endogenous or exogenous cannabinoids are present, these bind to the receptors and trigger a "cornucopia" of chemical signals. See also this. Cannabis is thus likely involved in more than just the facilitation of connection.
Stockton (2017). Scientists map the receptor that makes weed work. Wired. 
Wikipedia. Cannabinoid Receptor. 
Sosteric, Mike (2018). Safe use of connection supplements. Lightning Path 
Sharp, Michael (BOOK1). Lightning Path Workbook One: Introduction to Authentic Spirituality. Lightning Path Press. 
Sharp, Michael (BOOK2). Lightning Path Workbook Two: Healing. Lightning Path Press. 
Sharp, Michael (BOOK3). Lightning Path Workbook Three: Connection. Lightning Path Press.