Activation (also referred to as "empowerment") occurs when an individual, or a collective, embraces creative power and becomes an active and empowered change agent in the world.
Activation occurs first at the individual level, then at the collective level, and finally at the planetary level. The global activation process is visually illustrated in the Great Invocation meditation/visualization.
Under healthy global and social conditions (i.e. conditions filled with love, support, prosperity, grace, and guidance), activation occurs as a normal and safe part of the human development process.
In Eastern systems, activation may be conceived energetically as activation of the body's energy/Chakra System. Under healthy conditions, activation occurs when the energy systems of the physical unit (including the seven main chakras) mature and become fully active. Under unhealthy conditions, activation must be preceded by Healing.
Current planetary conditions are not healthy. Currently, we live with a Toxic Socialization process designed to prevent activation and prop up a destructive and venal System. The toxic socialization process is designed to suppress Consciousness (i.e. lower Consciousness Quotient) and distort and destroy the energy systems of the body in order to prevent activation. Therefore under current conditions activation often requires conscious, and possibly therapeutic, intervention.
Chelsea Handler, spurred by the horror she felt at the outcome of the 2016 U.S. elections, activated and became a change agent 
Activation -> Chakras
Sharp, Michael (GA). The Great Awakening: Concepts and Techniques for Successful Spiritual Practice.