Tobacco is a Connection Supplement used exclusively as such by North American Indigenous folks prior to European contact.
List of Connection Supplements
Connection Supplement > Ayahuasca, Cannabis, Chloroform, DMT, Haoma, Kaneh Bosm, Kava, Ketamine, Kykeon, LSD, MDMA, Maikua, Nitrous Oxide, Peyote, Psilocybin Mushroom, Santa Rosa, Soma, Tobacco, Yaqona
Tobacco is a Connection Supplement common among the indigenous North American people! "Prior to the coming of the Europeans, nowhere in Indian America was tobacco employed for anything but shamanistic and religious purposes. In South America, especially, the shamans of several indigenous societies still use it as an ecstatic intoxicant, alone, as among the Warao, or in combination with other psychotomimetic species." 
- Furst, Peter. “The Roots and Continuities of Shamanism.” Artscanada, 1974. p. 52.