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| A single inhalation of 5-MeO-DMT in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms.<ref>Uthaug, M. V., R. Lancelotta, K. van Oorsouw, K. P. C. Kuypers, N. Mason, J. Rak, A. Šuláková, et al. “A Single Inhalation of Vapor from Dried Toad Secretion Containing 5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT) in a Naturalistic Setting Is Related to Sustained Enhancement of Satisfaction with Life, Mindfulness-Related Capacities, and a Decrement of Psychopathological Symptoms.” ''Psychopharmacology'' 236, no. 9 (September 2019): 2653–66. https://doi.org/10.1007/s00213-019-05236-w.</ref> | | A single inhalation of 5-MeO-DMT in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms.<ref>Uthaug, M. V., R. Lancelotta, K. van Oorsouw, K. P. C. Kuypers, N. Mason, J. Rak, A. Šuláková, et al. “A Single Inhalation of Vapor from Dried Toad Secretion Containing 5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT) in a Naturalistic Setting Is Related to Sustained Enhancement of Satisfaction with Life, Mindfulness-Related Capacities, and a Decrement of Psychopathological Symptoms.” ''Psychopharmacology'' 236, no. 9 (September 2019): 2653–66. https://doi.org/10.1007/s00213-019-05236-w.</ref> |
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| | Speck Sheet - https://thethirdwave.co/psychedelics/5-meo-dmt/ |
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| '''Cognitive''' | | '''Cognitive''' |
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| LSD has nootropic properties.<ref>Dolan, Eric W. “Neuroscience Research Suggests LSD Might Enhance Learning and Memory by Promoting Brain Plasticity.” PsyPost, August 11, 2022. <nowiki>https://www.psypost.org/2022/08/neuroscience-research-suggests-lsd-might-enhance-learning-and-memory-by-promoting-brain-plasticity-63701</nowiki>.</ref> LSD " LSD increased markers of neuroplasticity in human brain organoids, increased novelty preference in rats, and improved memory performance in humans." For the scholarly article behind the news articles, [https://www.sciencedirect.com/science/article/abs/pii/S001448862200173X see this link].<ref>Ornelas, Isis M., Felipe A. Cini, Isabel Wießner, Encarni Marcos, Dráulio B. Araújo, Livia Goto-Silva, Juliana Nascimento, et al. “Nootropic Effects of LSD: Behavioral, Molecular and Computational Evidence.” ''Experimental Neurology'' 356 (October 1, 2022): 114148. <nowiki>https://doi.org/10.1016/j.expneurol.2022.114148</nowiki>.</ref>
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| LSD makes the mouse more social.<ref>Inserra, Antonio, Giada Giorgini, Sebastien Lacroix, Antonella Bertazzo, Jocelyn Choo, Athanasios Markopolous, Emily Grant, et al. “Effects of Repeated Lysergic Acid Diethylamide (LSD) on the Mouse Brain Endocannabinoidome and Gut Microbiome.” ''British Journal of Pharmacology'', October 31, 2022. https://doi.org/10.1111/bph.15977</ref>
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| LSD is a "chemical able to produce profound changes of consciousness...and...far reaching insights into one's own self and...one's relationship to others. Some takers of it have even felt that they had won an insight into the 'nature of the Universe and the purpose of Life.'...These insights can be remembered and, if the person wishes, can be incorporated into his or her everyday life to bring it a "better order."<ref>Heard, Gerald. "Can This Drug Enlarge Man's Mind?" Psychedelic Review 1 1 (1963). pp. 9</ref>
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| LSD increases awareness and intensifies perception, enhances creativity, reduces fear (of death for e.g.), distorts time, and is "eudaemonic,"<ref>Heard, Gerald. "Can This Drug Enlarge Man's Mind?" Psychedelic Review 1 1 (1963). pp. 9.</ref> but not always. "As I’d discovered to my regret, if you take mushrooms or acid when you feel low, they do not enhance your mood, but instead exacerbate your anxiety and distress."<ref>Szalavitz, Maia. Unbroken Brain: A Revolutionary New Way of Understanding Addiction (pp. 106-107). St. Martin's Press. Kindle Edition.</ref>
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| When LSD was first discovered, it was quickly recognized as having both healing and spiritual import. Morgar<ref>Mogar, R. E. “Current Status and Future Trends in Psychedelic (LSD) Research.” Journal of Humanistic Psychology 2 (1965): 147–66.</ref> notes, "the major application of LSD today is to ''treat'' mental illness...", something which it proved particularly adept at doing. Pahnke echoes this sentiment noting that "in the 1940's ... interest in psychedelic drugs as an experimental psychiatric tool became widespread." <ref>Pahnke, Walter N. “Psychedelic Drugs and Mystical Experience.” International Journal of Psychiatry in Clinical Practice, 1969. p. 158.</ref>
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| A growing body of research indicates the healing potential of LSD and other [[Connection Supplements]]<ref>Rootman, Joseph M., Pamela Kryskow, Kalin Harvey, Paul Stamets, Eesmyal Santos-Brault, Kim P. C. Kuypers, Vince Polito, Francoise Bourzat, and Zach Walsh. “Adults Who Microdose Psychedelics Report Health Related Motivations and Lower Levels of Anxiety and Depression Compared to Non-Microdosers.” Scientific Reports 11, no. 1 (November 18, 2021): 22479. https://doi.org/10.1038/s41598-021-01811-4.</ref>
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| Treatment of mental illness is facilitated by increased neuritogenesis, spinogenesis, and synaptogenesis.<ref>Ly, Calvin, Alexandra C. Greb, Lindsay P. Cameron, Jonathan M. Wong, Eden V. Barragan, Paige C. Wilson, Kyle F. Burbach, et al. “Psychedelics Promote Structural and Functional Neural Plasticity.” Cell Reports 23, no. 11 (June 12, 2018): 3170–82. https://doi.org/10.1016/j.celrep.2018.05.022</ref>
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| Morgar notes, LSD can be used in two modalities. "One emphasizes the use of LSD periodically and in small doses as an adjunct to traditional techniques of psychotherapy (Crockett, et al., 1963). The other major approach employs LSD in a single, large dose, producing an intense and prolonged psychedelic experience. Applied in this manner, LSD serves as a catalyst for inducing rapid and profound changes in the subject's value-belief system and in his self-image...."<ref>Mogar, R. E. “Current Status and Future Trends in Psychedelic (LSD) Research.” Journal of Humanistic Psychology 2 (1965): 156.</ref> The latter technique "places greater emphasis on its more unique potentialities and value, namely, as a means of facilitating personal growth and self-actualization. Rather than freedom from emotional symptoms, the primary objective of the psychedelic experience becomes a major reorganization of one's beliefs and life outlook. In short, the first method is essentially illness-oriented, the second, health or growth oriented." <ref>Mogar, R. E. “Current Status and Future Trends in Psychedelic (LSD) Research.” Journal of Humanistic Psychology 2 (1965): 156-7.</ref> He continues "When employed as an adjunct to psychotherapy, most investigators have associated the beneficial effects of LSD with reduced defensiveness, the reliving of early childhood experiences, increased access to unconscious material, and greater emotional expression. In contrast, when used as a primary vehicle for rapid personality change, emphasis is usually placed on the transcendental quality of the experience, the resynthesis of basic values and beliefs, and major changes in the relationship between self and environment." <ref>Mogar, R. E. “Current Status and Future Trends in Psychedelic (LSD) Research.” Journal of Humanistic Psychology 2 (1965): 157.</ref> In other words, as a [[Connection Supplement]], LSD can be used to [[Heal]] and [[Connection]]
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| ==Klee==
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| Klee<ref>Klee, G D. “Lysergic Acid Diethylamide (LSD-25) and Ego Functions.” Archives Of General Psychiatry 8 (May 1963): 461–74.</ref> notes that LSD operates by breaking down ego barriers (by suppressing the [[Bodily Ego]]). This operates at two levels. One is to reduce the individual's ability to filter stimuli, and the other is to reduce the ability of the [[Bodily Ego]] to mobilize defence mechanisms.
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| On inability to filter stimulu: "There is some reason to suspect that integrative mechanisms within the central nervous system (CNS) which handle inflowing stimuli are no longer able to limit the spread of excitation in the usual ways."<ref>Klee, G D. “Lysergic Acid Diethylamide (LSD-25) and Ego Functions.” Archives Of General Psychiatry 8 (May 1963): 465.</ref> Note in this context the phenomenon of [[Flooding]], which is a [[Connection Outcome]]. Klee actually uses the term flooding to describe the stimulus overload that can occur. Klee notes several dimension of cognitive impairment, particularly at high doses.
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| On the impact of LSD on the Bodily Ego and bodily ego defense mechanism "It is generally remarked that LSD dissolves the repressive barriers, or that defense mechanisms are generally impaired. These statements, in my opinion, are not entirely accurate. It is true that the subject's ability to repress is likely to be impaired. But as these barriers are lowered, and charged material threatens to enter awareness, an increased mobilization of repressive efforts often occurs in waves, operating massively and crudely to block out not only the threatening material but much associated material as well. As repression fails further, various other more regressive mechanisms are brought into play, such as denial and projection. Only occasionally will defense mechanisms fail almost entirely in certain subjects and a panic state ensue. More often, new defenses are brought into play, and the subject reaches relative equilibrium at a more regressed level. Certain mechanisms, especially repression and reaction formation, appear to be most vulnerable to LSD. Other, presumably more primitive defenses, such as regression denial, introjection, and projection, may function very effectively. For example, some predisposed subjects are capable of developing highly systematized paranoid delusions under the effects of marked LSD intoxication. In each case, subjects tend to fall back on those defenses which are most available to them, based upon their personality structures."<ref>Klee, G D. “Lysergic Acid Diethylamide (LSD-25) and Ego Functions.” Archives Of General Psychiatry 8 (May 1963): 470-1.</ref>
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| The loss of "stimulus barries" and the negation of defense mechanisms may lead to [[Zenith Experience]]s, but they may also cause difficulty, particularly in cases where the [[Bodily Ego]] is damaged by [[Toxic Socialization]]. "The consequences to the subject of the apparent loss of stimulus barriers is in some respects analogous to the situation in a traumatic neurosis. Only in this case it needs a much milder stimulus to produce traumatic effects. Thus, a slightly threatening situation, such as mild reprobation, scorn, or unfriendliness from another person, may loom large and ominous to the subject. Strong affective reactions may occur with what appears to be only the slightest provocation."<ref>Klee, G D. “Lysergic Acid Diethylamide (LSD-25) and Ego Functions.” Archives Of General Psychiatry 8 (May 1963): 467.</ref> When interacting with an individual with severe damage, caution should be exercised. "On some occasions during our studies we have seen subjects who found it difficult or impossible to control their behavior. These were usually persons who were rather aggressive and impulsive to begin with, but it sometimes occurs in other types. In the experimental setting, of course, these subjects were usually friendly and cooperative initially, but after taking LSD they found themselves overwhelmed with impulses, often of an assaultive nature. These feelings sometimes appeared to arise spontaneously or were provoked by a relatively slight incident, such as a painful venipuncture or a witticism directed at them by another subject. A subject at such times
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| could barely resist putting his impulses into action. He would pace about, clench his fists, and grind his teeth to maintain control. Sometimes full-blown panic would ensue in the face of homicidal impulses which the subject felt he might be unable to control. One subject developed what appeared to be an hysterical paralysis of his limbs, apparently as a last-ditch control against assaultive behavior."<ref>Klee, G D. “Lysergic Acid Diethylamide (LSD-25) and Ego Functions.” Archives Of General Psychiatry 8 (May 1963): 471.</ref>
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| == Anecdotes == | | == Anecdotes == |
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| Eating Disorder
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| https://www.reddit.com/r/RationalPsychonaut/comments/vs6v1o/i_cured_my_disordered_eating_with_lsd/
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| Awakening to reality
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| * https://www.reddit.com/r/LSD/comments/sxp477/this_society_is_poison/
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| Weight Loss
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| * https://www.reddit.com/r/LSD/comments/r9bbcd/update_post_last_march_lsd_inspired_me_to_start_a/
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| * https://www.reddit.com/r/LSD/comments/rm5jdl/update_few_months_later_after_bad_trip/
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| Improves cognitive functions (7-8 ug). https://www.reddit.com/r/LSD/comments/rbrxvu/coding_its_so_fun_on_a_microdose/
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| Curing addiction
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| * to alcohol https://www.reddit.com/r/LSD/comments/rvp2f2/ive_been_alcohol_free_for_100_days_after_taking/
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| *to alcohol https://www.reddit.com/r/Psychonaut/comments/wuua1b/i_think_lsd_may_have_killed_my_desire_to_drink/
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| Mental Health
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| * Used to facilitate mental healing and mental health https://www.reddit.com/r/LSD/comments/s7siio/self_medicating_my_mental_illnesses_with_lsd/
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| [[Transformation''
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| [[Grof, Stanislav|Stanislav Grof]] got started on his transpersonal path with a profound LSD experience he had while volunteering as a subject in LSD trials. <ref>Grof, Stanislav. ''When the Impossible Happens.'' Boulder, CO: Sounds True, 2006.</ref> In this experience he confronted his unconscious psyche, downloaded a shit ton of information, and finally experienced an expansion of consciousness to cosmic levels.<ref>Grof, Stanislav. ''When the Impossible Happens.'' Boulder, CO: Sounds True, 2006.</ref>
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| == Additional Reading ==
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| * [https://en.wikipedia.org/wiki/Lysergic_acid_diethylamide#Spiritual Wikipedia entry LSD]
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| * [https://www.trippingly.net/lsd/lsd-trip-length-duration-and-intensity LSD Trip Length / Duration and Intensity - Guidance]
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| * [https://www.verywellmind.com/what-does-it-feel-like-to-get-high-on-acid-21886 Understanding the Acid Trip Experience]
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| {{template:endstuff}} | | {{template:endstuff}} |
5-MEO DMT is short duration, high power Connection Supplement. It is found in the secretion of the parotoid glands of the Bufo alvarius toad. Inhalation of vapor from toad secretion containing 5-MeO-DMT has become popular in naturalistic settings as a treatment of mental health problems or as a means for spiritual exploration.
List of Connection Supplements
Connection Supplement > 5-MEO DMT, Ayahuasca, Cannabis, Chloroform, DMT, Datura, Haoma, Kaneh Bosm, Kava, Ketamine, Kykeon, LSD, MDMA, Maikua, Manna, Nitrous Oxide, Peyote, Psilocybin Mushroom, Santa Rosa, Soma, Tobacco, Yaqona
Related LP Terms
Connection Supplement > Connection Axes, Connection Coach, Connection Companion, Connection Therapy, Crown Stupifier, Disjuncture
Related Terms
Connection Supplement > Womb Room
Notes
5-MEO DMT acts as a serotonin 5-HT-1-A/5-HT-2A/C receptor agonist and induces a diversity of subjective effects, including auditory, visual, and time perception distortions, emotional experiences, and memory impairment that vary depending on the dose and route of administration [3].
Recent studies have suggested that 5-MeO-DMT may have psychotherapeutic effects and may enhance mood in general or may be particularly mood enhancing for those experiencing clinically significant negative affect [2][4][5].
A single inhalation of 5-MeO-DMT in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms.[1]
Speck Sheet - https://thethirdwave.co/psychedelics/5-meo-dmt/
Enhancements
Affective
Cognitive
Creative
Empathic
Cognitive
Anecdotes
- ↑ Uthaug, M. V., R. Lancelotta, K. van Oorsouw, K. P. C. Kuypers, N. Mason, J. Rak, A. Šuláková, et al. “A Single Inhalation of Vapor from Dried Toad Secretion Containing 5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT) in a Naturalistic Setting Is Related to Sustained Enhancement of Satisfaction with Life, Mindfulness-Related Capacities, and a Decrement of Psychopathological Symptoms.” Psychopharmacology 236, no. 9 (September 2019): 2653–66. https://doi.org/10.1007/s00213-019-05236-w.
