https://spiritwiki.lightningpath.org/index.php?action=history&feed=atom&title=Psilocybin_Mushroom
Psilocybin Mushroom - Revision history
2026-05-12T23:12:11Z
Revision history for this page on the wiki
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https://spiritwiki.lightningpath.org/index.php?title=Psilocybin_Mushroom&diff=28178&oldid=prev
Michael at 12:36, 2 November 2024
2024-11-02T12:36:21Z
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><blockquote class="definition">'''Psilocybin Mushrooms''' are [[Connection Supplements]] popular amongst ancient Mesoamericans, but forced under ground by <del style="font-weight: bold; text-decoration: none;">the </del>the western Church when it participated in the colonization of America's native people.<ref>Estrada, Alvaro. Maria Sabina: Her Life and Chants. Translated by Henry Munn. Santa Barbara, California: Ross-Erikson, 1981</ref> </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><blockquote class="definition">'''Psilocybin Mushrooms''' are [[Connection Supplements]] popular amongst ancient Mesoamericans, but forced under ground by the western Church when it participated in the colonization of America's native people.<ref>Estrada, Alvaro. Maria Sabina: Her Life and Chants. Translated by Henry Munn. Santa Barbara, California: Ross-Erikson, 1981</ref> </div></td></tr>
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Michael
https://spiritwiki.lightningpath.org/index.php?title=Psilocybin_Mushroom&diff=26739&oldid=prev
Michael at 15:26, 24 September 2023
2023-09-24T15:26:14Z
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<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* [https://www.nature.com/articles/s41598-023-40856-5 Co-use of MDMA with psilocybin/LSD may buffer against challenging experiences and enhance positive experiences]<ref>Zeifman, Richard J., Hannes Kettner, Broc A. Pagni, Austin Mallard, Daniel E. Roberts, David Erritzoe, Stephen Ross, and Robin L. Carhart-Harris. “Co-Use of MDMA with Psilocybin/LSD May Buffer against Challenging Experiences and Enhance Positive Experiences.” ''Scientific Reports'' 13, no. 1 (August 22, 2023): 13645. <nowiki>https://doi.org/10.1038/s41598-023-40856-5</nowiki>.</ref></ins></div></td></tr>
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Michael
https://spiritwiki.lightningpath.org/index.php?title=Psilocybin_Mushroom&diff=26675&oldid=prev
Michael at 13:17, 30 August 2023
2023-08-30T13:17:14Z
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Lifetime use of LSD, MDMA, and Psilocybin mushrooms is associated with significantly lower rates of major depressive episodes (MDEs). Jones et al. finds that Psilocybin is associated with reduced past-year MDEs whereas LSD/MDMA are associated with a global reduction in MDEs. <ref>Grant M. Jones and Matthew K. Nock, “Lifetime Use of MDMA/Ecstasy and Psilocybin Is Associated with Reduced Odds of Major Depressive Episodes,” ''Journal of Psychopharmacology'' 36, no. 1 (January 2022): 57–65, <nowiki>https://doi.org/10.1177/02698811211066714</nowiki>.</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Lifetime use of LSD, MDMA, and Psilocybin mushrooms is associated with significantly lower rates of major depressive episodes (MDEs). Jones et al. finds that Psilocybin is associated with reduced past-year MDEs whereas LSD/MDMA are associated with a global reduction in MDEs. <ref>Grant M. Jones and Matthew K. Nock, “Lifetime Use of MDMA/Ecstasy and Psilocybin Is Associated with Reduced Odds of Major Depressive Episodes,” ''Journal of Psychopharmacology'' 36, no. 1 (January 2022): 57–65, <nowiki>https://doi.org/10.1177/02698811211066714</nowiki>.</ref></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>"A single dose of psilocybin facilitated rapid and sustained fear extinction; this effect might be partially mediated by the promotion of hippocampal neuroplasticity. This study indicates that psilocybin may be a useful adjunct to exposure-based therapies for PTSD and other mental disorders characterized by failure of fear extinction."<ref>Du, Yingjie, Yunfeng Li, Xiangting Zhao, Yishan Yao, Bin Wang, Liming Zhang, and Guyan Wang. “Psilocybin Facilitates Fear Extinction in Mice by Promoting Hippocampal Neuroplasticity.” ''Chinese Medical Journal'', 9900. <nowiki>https://journals.lww.com/cmj/Fulltext/9900/Psilocybin_facilitates_fear_extinction_in_mice_by.497.aspx</nowiki>.</ref> </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>"A single dose of psilocybin facilitated rapid and sustained fear extinction; this effect might be partially mediated by the promotion of hippocampal neuroplasticity. This study indicates that psilocybin may be a useful adjunct to exposure-based therapies for PTSD and other mental disorders characterized by failure of fear extinction."<ref>Du, Yingjie, Yunfeng Li, Xiangting Zhao, Yishan Yao, Bin Wang, Liming Zhang, and Guyan Wang. “Psilocybin Facilitates Fear Extinction in Mice by Promoting Hippocampal Neuroplasticity.” ''Chinese Medical Journal'', 9900. <nowiki>https://journals.lww.com/cmj/Fulltext/9900/Psilocybin_facilitates_fear_extinction_in_mice_by.497.aspx</nowiki>.</ref></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Mushrooms can be challenging. In one study, 38% of respondents indicated a mushroom trip to be one of the five most challenging experiences of their life. However, out of 1993 respondents, only 3 indicated enduring psychotic episodes (.1 percent), and only 3 indicated suicide attempts.<ref>Carbonaro, Theresa M., Matthew P. Bradstreet, Frederick S. Barrett, Katherine A. MacLean, Robert Jesse, Matthew W. Johnson, and Roland R. Griffiths. “Survey Study of Challenging Experiences after Ingesting Psilocybin Mushrooms: Acute and Enduring Positive and Negative Consequences.” ''Journal of Psychopharmacology (Oxford, England)'' 30, no. 12 (December 2016): 1268–78. <nowiki>https://doi.org/10.1177/0269881116662634</nowiki>.</ref> Even though challenging, 84% endorsed the experience.<ref>Carbonaro, Theresa M., Matthew P. Bradstreet, Frederick S. Barrett, Katherine A. MacLean, Robert Jesse, Matthew W. Johnson, and Roland R. Griffiths. “Survey Study of Challenging Experiences after Ingesting Psilocybin Mushrooms: Acute and Enduring Positive and Negative Consequences.” ''Journal of Psychopharmacology (Oxford, England)'' 30, no. 12 (December 2016): 1268–78. https://doi.org/10.1177/0269881116662634.&#x3C;/ref></ref> This study also notes that set, setting, and the availability of expertise and social supports mitigate negative experiences. </ins></div></td></tr>
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Michael
https://spiritwiki.lightningpath.org/index.php?title=Psilocybin_Mushroom&diff=25531&oldid=prev
Michael at 18:14, 2 April 2023
2023-04-02T18:14:16Z
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Psilocybin effects of psilocybin are mediated/reflected in the agonism of the serotonin 2A receptor (5-HT2AR), as measured via PET scans.<ref>Stenbæk, Dea Siggaard, Martin Korsbak Madsen, Brice Ozenne, Sara Kristiansen, Daniel Burmester, David Erritzoe, Gitte Moos Knudsen, and Patrick MacDonald Fisher. “Brain Serotonin 2A Receptor Binding Predicts Subjective Temporal and Mystical Effects of Psilocybin in Healthy Humans.” ''Journal of Psychopharmacology'' 35, no. 4 (April 1, 2021): 459–68. <nowiki>https://doi.org/10.1177/0269881120959609</nowiki>.</ref> Note, given the difficulty of obtaining large PET scans, there is a high correlation between plasma psilocin and 5-HT2AR occupancy; thus, plasma psilocin levels may be used as an accurate surrogate.<ref>Stenbæk, Dea Siggaard, Martin Korsbak Madsen, Brice Ozenne, Sara Kristiansen, Daniel Burmester, David Erritzoe, Gitte Moos Knudsen, and Patrick MacDonald Fisher. “Brain Serotonin 2A Receptor Binding Predicts Subjective Temporal and Mystical Effects of Psilocybin in Healthy Humans.” ''Journal of Psychopharmacology'' 35, no. 4 (April 1, 2021): 459–68. <nowiki>https://doi.org/10.1177/0269881120959609</nowiki>.</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Psilocybin effects of psilocybin are mediated/reflected in the agonism of the serotonin 2A receptor (5-HT2AR), as measured via PET scans.<ref>Stenbæk, Dea Siggaard, Martin Korsbak Madsen, Brice Ozenne, Sara Kristiansen, Daniel Burmester, David Erritzoe, Gitte Moos Knudsen, and Patrick MacDonald Fisher. “Brain Serotonin 2A Receptor Binding Predicts Subjective Temporal and Mystical Effects of Psilocybin in Healthy Humans.” ''Journal of Psychopharmacology'' 35, no. 4 (April 1, 2021): 459–68. <nowiki>https://doi.org/10.1177/0269881120959609</nowiki>.</ref> Note, given the difficulty of obtaining large PET scans, there is a high correlation between plasma psilocin and 5-HT2AR occupancy; thus, plasma psilocin levels may be used as an accurate surrogate.<ref>Stenbæk, Dea Siggaard, Martin Korsbak Madsen, Brice Ozenne, Sara Kristiansen, Daniel Burmester, David Erritzoe, Gitte Moos Knudsen, and Patrick MacDonald Fisher. “Brain Serotonin 2A Receptor Binding Predicts Subjective Temporal and Mystical Effects of Psilocybin in Healthy Humans.” ''Journal of Psychopharmacology'' 35, no. 4 (April 1, 2021): 459–68. <nowiki>https://doi.org/10.1177/0269881120959609</nowiki>.</ref></div></td></tr>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Lifetime use of LSD, MDMA, and Psilocybin mushrooms is associated with significantly lower rates of major depressive episodes (MDEs). Jones et al. finds that Psilocybin is associated with reduced past-year MDEs whereas LSD/MDMA are associated with a global reduction in MDEs. <ref>Grant M. Jones and Matthew K. Nock, “Lifetime Use of MDMA/Ecstasy and Psilocybin Is Associated with Reduced Odds of Major Depressive Episodes,” ''Journal of Psychopharmacology'' 36, no. 1 (January 2022): 57–65, <nowiki>https://doi.org/10.1177/02698811211066714</nowiki>.</ref> </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Lifetime use of LSD, MDMA, and Psilocybin mushrooms is associated with significantly lower rates of major depressive episodes (MDEs). Jones et al. finds that Psilocybin is associated with reduced past-year MDEs whereas LSD/MDMA are associated with a global reduction in MDEs. <ref>Grant M. Jones and Matthew K. Nock, “Lifetime Use of MDMA/Ecstasy and Psilocybin Is Associated with Reduced Odds of Major Depressive Episodes,” ''Journal of Psychopharmacology'' 36, no. 1 (January 2022): 57–65, <nowiki>https://doi.org/10.1177/02698811211066714<ins style="font-weight: bold; text-decoration: none;"></nowiki>.</ref></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">"A single dose of psilocybin facilitated rapid and sustained fear extinction; this effect might be partially mediated by the promotion of hippocampal neuroplasticity. This study indicates that psilocybin may be a useful adjunct to exposure-based therapies for PTSD and other mental disorders characterized by failure of fear extinction."<ref>Du, Yingjie, Yunfeng Li, Xiangting Zhao, Yishan Yao, Bin Wang, Liming Zhang, and Guyan Wang. “Psilocybin Facilitates Fear Extinction in Mice by Promoting Hippocampal Neuroplasticity.” ''Chinese Medical Journal'', 9900. <nowiki>https://journals.lww.com/cmj/Fulltext/9900/Psilocybin_facilitates_fear_extinction_in_mice_by.497.aspx</ins></nowiki>.</ref> </div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''Treatment'''</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''Treatment'''</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''Additional'''</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''Additional'''</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Mushrooms visualized as little male or female beings, elves, duendes, tricksters, ''saint children,'' the blood of Christ..<ref>Estrada, Alvaro. Maria Sabina: Her Life and Chants. Translated by Henry Munn. Santa Barbara, California: Ross-Erikson, 1981.</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Mushrooms visualized as little male or female beings, elves, duendes, tricksters, ''saint children,'' the blood of Christ..<ref>Estrada, Alvaro. Maria Sabina: Her Life and Chants. Translated by Henry Munn. Santa Barbara, California: Ross-Erikson, 1981.</ref></div></td></tr>
</table>
Michael
https://spiritwiki.lightningpath.org/index.php?title=Psilocybin_Mushroom&diff=25116&oldid=prev
Tristan at 18:44, 11 January 2023
2023-01-11T18:44:12Z
<p></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 18:44, 11 January 2023</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Notes==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Notes==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>'''Action and Measurement''</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>'''Action and Measurement<ins style="font-weight: bold; text-decoration: none;">'</ins>''</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Psilocybin effects of psilocybin are mediated/reflected in the agonism of the serotonin 2A receptor (5-HT2AR), as measured via PET scans.<ref>Stenbæk, Dea Siggaard, Martin Korsbak Madsen, Brice Ozenne, Sara Kristiansen, Daniel Burmester, David Erritzoe, Gitte Moos Knudsen, and Patrick MacDonald Fisher. “Brain Serotonin 2A Receptor Binding Predicts Subjective Temporal and Mystical Effects of Psilocybin in Healthy Humans.” ''Journal of Psychopharmacology'' 35, no. 4 (April 1, 2021): 459–68. <nowiki>https://doi.org/10.1177/0269881120959609</nowiki>.</ref> Note, given the difficulty of obtaining large PET scans, there is a high correlation between plasma psilocin and 5-HT2AR occupancy; thus, plasma psilocin levels may be used as an accurate surrogate.<ref>Stenbæk, Dea Siggaard, Martin Korsbak Madsen, Brice Ozenne, Sara Kristiansen, Daniel Burmester, David Erritzoe, Gitte Moos Knudsen, and Patrick MacDonald Fisher. “Brain Serotonin 2A Receptor Binding Predicts Subjective Temporal and Mystical Effects of Psilocybin in Healthy Humans.” ''Journal of Psychopharmacology'' 35, no. 4 (April 1, 2021): 459–68. <nowiki>https://doi.org/10.1177/0269881120959609</nowiki>.</ref> </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Psilocybin effects of psilocybin are mediated/reflected in the agonism of the serotonin 2A receptor (5-HT2AR), as measured via PET scans.<ref>Stenbæk, Dea Siggaard, Martin Korsbak Madsen, Brice Ozenne, Sara Kristiansen, Daniel Burmester, David Erritzoe, Gitte Moos Knudsen, and Patrick MacDonald Fisher. “Brain Serotonin 2A Receptor Binding Predicts Subjective Temporal and Mystical Effects of Psilocybin in Healthy Humans.” ''Journal of Psychopharmacology'' 35, no. 4 (April 1, 2021): 459–68. <nowiki>https://doi.org/10.1177/0269881120959609</nowiki>.</ref> Note, given the difficulty of obtaining large PET scans, there is a high correlation between plasma psilocin and 5-HT2AR occupancy; thus, plasma psilocin levels may be used as an accurate surrogate.<ref>Stenbæk, Dea Siggaard, Martin Korsbak Madsen, Brice Ozenne, Sara Kristiansen, Daniel Burmester, David Erritzoe, Gitte Moos Knudsen, and Patrick MacDonald Fisher. “Brain Serotonin 2A Receptor Binding Predicts Subjective Temporal and Mystical Effects of Psilocybin in Healthy Humans.” ''Journal of Psychopharmacology'' 35, no. 4 (April 1, 2021): 459–68. <nowiki>https://doi.org/10.1177/0269881120959609<ins style="font-weight: bold; text-decoration: none;"></nowiki>.</ref></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Lifetime use of LSD, MDMA, and Psilocybin mushrooms is associated with significantly lower rates of major depressive episodes (MDEs). Jones et al. finds that Psilocybin is associated with reduced past-year MDEs whereas LSD/MDMA are associated with a global reduction in MDEs. <ref>Grant M. Jones and Matthew K. Nock, “Lifetime Use of MDMA/Ecstasy and Psilocybin Is Associated with Reduced Odds of Major Depressive Episodes,” ''Journal of Psychopharmacology'' 36, no. 1 (January 2022): 57–65, <nowiki>https://doi.org/10.1177/02698811211066714</ins></nowiki>.</ref> </div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
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</table>
Tristan
https://spiritwiki.lightningpath.org/index.php?title=Psilocybin_Mushroom&diff=24869&oldid=prev
Tristan: /* Notes */
2023-01-06T18:37:25Z
<p><span class="autocomment">Notes</span></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 18:37, 6 January 2023</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>'''Action and <del style="font-weight: bold; text-decoration: none;">Measurment'</del>''</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>'''Action and <ins style="font-weight: bold; text-decoration: none;">Measurement</ins>''</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Psilocybin effects of psilocybin are mediated/reflected in the agonism of the serotonin 2A receptor (5-HT2AR), as measured via PET scans.<ref>Stenbæk, Dea Siggaard, Martin Korsbak Madsen, Brice Ozenne, Sara Kristiansen, Daniel Burmester, David Erritzoe, Gitte Moos Knudsen, and Patrick MacDonald Fisher. “Brain Serotonin 2A Receptor Binding Predicts Subjective Temporal and Mystical Effects of Psilocybin in Healthy Humans.” ''Journal of Psychopharmacology'' 35, no. 4 (April 1, 2021): 459–68. <nowiki>https://doi.org/10.1177/0269881120959609</nowiki>.</ref> Note, given the difficulty of obtaining large PET scans, there is a high correlation between plasma psilocin and 5-HT2AR occupancy; thus, plasma psilocin levels may be used as an accurate surrogate.<ref>Stenbæk, Dea Siggaard, Martin Korsbak Madsen, Brice Ozenne, Sara Kristiansen, Daniel Burmester, David Erritzoe, Gitte Moos Knudsen, and Patrick MacDonald Fisher. “Brain Serotonin 2A Receptor Binding Predicts Subjective Temporal and Mystical Effects of Psilocybin in Healthy Humans.” ''Journal of Psychopharmacology'' 35, no. 4 (April 1, 2021): 459–68. <nowiki>https://doi.org/10.1177/0269881120959609</nowiki>.</ref> </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Psilocybin effects of psilocybin are mediated/reflected in the agonism of the serotonin 2A receptor (5-HT2AR), as measured via PET scans.<ref>Stenbæk, Dea Siggaard, Martin Korsbak Madsen, Brice Ozenne, Sara Kristiansen, Daniel Burmester, David Erritzoe, Gitte Moos Knudsen, and Patrick MacDonald Fisher. “Brain Serotonin 2A Receptor Binding Predicts Subjective Temporal and Mystical Effects of Psilocybin in Healthy Humans.” ''Journal of Psychopharmacology'' 35, no. 4 (April 1, 2021): 459–68. <nowiki>https://doi.org/10.1177/0269881120959609</nowiki>.</ref> Note, given the difficulty of obtaining large PET scans, there is a high correlation between plasma psilocin and 5-HT2AR occupancy; thus, plasma psilocin levels may be used as an accurate surrogate.<ref>Stenbæk, Dea Siggaard, Martin Korsbak Madsen, Brice Ozenne, Sara Kristiansen, Daniel Burmester, David Erritzoe, Gitte Moos Knudsen, and Patrick MacDonald Fisher. “Brain Serotonin 2A Receptor Binding Predicts Subjective Temporal and Mystical Effects of Psilocybin in Healthy Humans.” ''Journal of Psychopharmacology'' 35, no. 4 (April 1, 2021): 459–68. <nowiki>https://doi.org/10.1177/0269881120959609</nowiki>.</ref> </div></td></tr>
</table>
Tristan
https://spiritwiki.lightningpath.org/index.php?title=Psilocybin_Mushroom&diff=24863&oldid=prev
Michael at 15:54, 3 January 2023
2023-01-03T15:54:35Z
<p></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 15:54, 3 January 2023</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l10">Line 10:</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Notes==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Notes==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''Action and Measurment'''</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''Action and Measurment'''</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Psilocybin effects of psilocybin are mediated/reflected in the agonism of the serotonin 2A receptor (5-HT2AR), as measured via PET scans.<ref>Stenbæk, Dea Siggaard, Martin Korsbak Madsen, Brice Ozenne, Sara Kristiansen, Daniel Burmester, David Erritzoe, Gitte Moos Knudsen, and Patrick MacDonald Fisher. “Brain Serotonin 2A Receptor Binding Predicts Subjective Temporal and Mystical Effects of Psilocybin in Healthy Humans.” ''Journal of Psychopharmacology'' 35, no. 4 (April 1, 2021): 459–68. <nowiki>https://doi.org/10.1177/0269881120959609</nowiki>.</ref> Note, given the difficulty of obtaining large PET scans, there is a high correlation between plasma psilocin and 5-HT2AR occupancy; thus, plasma psilocin levels may be used as an accurate surrogate.<ref>Stenbæk, Dea Siggaard, Martin Korsbak Madsen, Brice Ozenne, Sara Kristiansen, Daniel Burmester, David Erritzoe, Gitte Moos Knudsen, and Patrick MacDonald Fisher. “Brain Serotonin 2A Receptor Binding Predicts Subjective Temporal and Mystical Effects of Psilocybin in Healthy Humans.” ''Journal of Psychopharmacology'' 35, no. 4 (April 1, 2021): 459–68. <nowiki>https://doi.org/10.1177/0269881120959609</nowiki>.</ref> </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Psilocybin effects of psilocybin are mediated/reflected in the agonism of the serotonin 2A receptor (5-HT2AR), as measured via PET scans.<ref>Stenbæk, Dea Siggaard, Martin Korsbak Madsen, Brice Ozenne, Sara Kristiansen, Daniel Burmester, David Erritzoe, Gitte Moos Knudsen, and Patrick MacDonald Fisher. “Brain Serotonin 2A Receptor Binding Predicts Subjective Temporal and Mystical Effects of Psilocybin in Healthy Humans.” ''Journal of Psychopharmacology'' 35, no. 4 (April 1, 2021): 459–68. <nowiki>https://doi.org/10.1177/0269881120959609</nowiki>.</ref> Note, given the difficulty of obtaining large PET scans, there is a high correlation between plasma psilocin and 5-HT2AR occupancy; thus, plasma psilocin levels may be used as an accurate surrogate.<ref>Stenbæk, Dea Siggaard, Martin Korsbak Madsen, Brice Ozenne, Sara Kristiansen, Daniel Burmester, David Erritzoe, Gitte Moos Knudsen, and Patrick MacDonald Fisher. “Brain Serotonin 2A Receptor Binding Predicts Subjective Temporal and Mystical Effects of Psilocybin in Healthy Humans.” ''Journal of Psychopharmacology'' 35, no. 4 (April 1, 2021): 459–68. <nowiki>https://doi.org/10.1177/0269881120959609</nowiki>.</ref> </div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">'''Treatment'''</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''Additional'''</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''Additional'''</div></td></tr>
</table>
Michael
https://spiritwiki.lightningpath.org/index.php?title=Psilocybin_Mushroom&diff=24862&oldid=prev
Michael at 15:53, 3 January 2023
2023-01-03T15:53:52Z
<p></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 15:53, 3 January 2023</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l12">Line 12:</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>'''Action'''</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>'''Action <ins style="font-weight: bold; text-decoration: none;">and Measurment</ins>'''</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Psilocybin effects of psilocybin are mediated/reflected in the agonism of the serotonin 2A receptor (5-HT2AR), as measured via PET scans.<ref>Stenbæk, Dea Siggaard, Martin Korsbak Madsen, Brice Ozenne, Sara Kristiansen, Daniel Burmester, David Erritzoe, Gitte Moos Knudsen, and Patrick MacDonald Fisher. “Brain Serotonin 2A Receptor Binding Predicts Subjective Temporal and Mystical Effects of Psilocybin in Healthy Humans.” ''Journal of Psychopharmacology'' 35, no. 4 (April 1, 2021): 459–68. <nowiki>https://doi.org/10.1177/0269881120959609</nowiki>.</ref> Note, given the difficulty of obtaining large PET scans, there is a high correlation between plasma psilocin and 5-HT2AR occupancy; thus, plasma psilocin levels may be used as an accurate surrogate.<ref>Stenbæk, Dea Siggaard, Martin Korsbak Madsen, Brice Ozenne, Sara Kristiansen, Daniel Burmester, David Erritzoe, Gitte Moos Knudsen, and Patrick MacDonald Fisher. “Brain Serotonin 2A Receptor Binding Predicts Subjective Temporal and Mystical Effects of Psilocybin in Healthy Humans.” ''Journal of Psychopharmacology'' 35, no. 4 (April 1, 2021): 459–68. <nowiki>https://doi.org/10.1177/0269881120959609</nowiki>.</ref> </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Psilocybin effects of psilocybin are mediated/reflected in the agonism of the serotonin 2A receptor (5-HT2AR), as measured via PET scans.<ref>Stenbæk, Dea Siggaard, Martin Korsbak Madsen, Brice Ozenne, Sara Kristiansen, Daniel Burmester, David Erritzoe, Gitte Moos Knudsen, and Patrick MacDonald Fisher. “Brain Serotonin 2A Receptor Binding Predicts Subjective Temporal and Mystical Effects of Psilocybin in Healthy Humans.” ''Journal of Psychopharmacology'' 35, no. 4 (April 1, 2021): 459–68. <nowiki>https://doi.org/10.1177/0269881120959609</nowiki>.</ref> Note, given the difficulty of obtaining large PET scans, there is a high correlation between plasma psilocin and 5-HT2AR occupancy; thus, plasma psilocin levels may be used as an accurate surrogate.<ref>Stenbæk, Dea Siggaard, Martin Korsbak Madsen, Brice Ozenne, Sara Kristiansen, Daniel Burmester, David Erritzoe, Gitte Moos Knudsen, and Patrick MacDonald Fisher. “Brain Serotonin 2A Receptor Binding Predicts Subjective Temporal and Mystical Effects of Psilocybin in Healthy Humans.” ''Journal of Psychopharmacology'' 35, no. 4 (April 1, 2021): 459–68. <nowiki>https://doi.org/10.1177/0269881120959609</nowiki>.</ref> </div></td></tr>
</table>
Michael
https://spiritwiki.lightningpath.org/index.php?title=Psilocybin_Mushroom&diff=24843&oldid=prev
Michael at 19:56, 31 December 2022
2022-12-31T19:56:44Z
<p></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 19:56, 31 December 2022</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''Action'''</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''Action'''</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Psilocybin effects of psilocybin are mediated/reflected in the agonism of the serotonin 2A receptor (5-HT2AR), as measured via PET scans.<ref>Stenbæk, Dea Siggaard, Martin Korsbak Madsen, Brice Ozenne, Sara Kristiansen, Daniel Burmester, David Erritzoe, Gitte Moos Knudsen, and Patrick MacDonald Fisher. “Brain Serotonin 2A Receptor Binding Predicts Subjective Temporal and Mystical Effects of Psilocybin in Healthy Humans.” ''Journal of Psychopharmacology'' 35, no. 4 (April 1, 2021): 459–68. <nowiki>https://doi.org/10.1177/0269881120959609</nowiki>.</ref> Note, given the difficulty of obtaining large PET scans, there is a high correlation between plasma psilocin and 5-HT2AR occupancy, plasma psilocin levels may be used <del style="font-weight: bold; text-decoration: none;"> </del>as an accurate surrogate.<ref>Stenbæk, Dea Siggaard, Martin Korsbak Madsen, Brice Ozenne, Sara Kristiansen, Daniel Burmester, David Erritzoe, Gitte Moos Knudsen, and Patrick MacDonald Fisher. “Brain Serotonin 2A Receptor Binding Predicts Subjective Temporal and Mystical Effects of Psilocybin in Healthy Humans.” ''Journal of Psychopharmacology'' 35, no. 4 (April 1, 2021): 459–68. <nowiki>https://doi.org/10.1177/0269881120959609</nowiki>.</ref> </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Psilocybin effects of psilocybin are mediated/reflected in the agonism of the serotonin 2A receptor (5-HT2AR), as measured via PET scans.<ref>Stenbæk, Dea Siggaard, Martin Korsbak Madsen, Brice Ozenne, Sara Kristiansen, Daniel Burmester, David Erritzoe, Gitte Moos Knudsen, and Patrick MacDonald Fisher. “Brain Serotonin 2A Receptor Binding Predicts Subjective Temporal and Mystical Effects of Psilocybin in Healthy Humans.” ''Journal of Psychopharmacology'' 35, no. 4 (April 1, 2021): 459–68. <nowiki>https://doi.org/10.1177/0269881120959609</nowiki>.</ref> Note, given the difficulty of obtaining large PET scans, there is a high correlation between plasma psilocin and 5-HT2AR occupancy<ins style="font-weight: bold; text-decoration: none;">; thus</ins>, plasma psilocin levels may be used as an accurate surrogate.<ref>Stenbæk, Dea Siggaard, Martin Korsbak Madsen, Brice Ozenne, Sara Kristiansen, Daniel Burmester, David Erritzoe, Gitte Moos Knudsen, and Patrick MacDonald Fisher. “Brain Serotonin 2A Receptor Binding Predicts Subjective Temporal and Mystical Effects of Psilocybin in Healthy Humans.” ''Journal of Psychopharmacology'' 35, no. 4 (April 1, 2021): 459–68. <nowiki>https://doi.org/10.1177/0269881120959609</nowiki>.</ref> </div></td></tr>
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Michael
https://spiritwiki.lightningpath.org/index.php?title=Psilocybin_Mushroom&diff=24840&oldid=prev
Michael at 19:50, 31 December 2022
2022-12-31T19:50:03Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 19:50, 31 December 2022</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Psilocybin effects of psilocybin are mediated/reflected in the agonism of the serotonin 2A receptor (5-HT2AR).<ref>Stenbæk, Dea Siggaard, Martin Korsbak Madsen, Brice Ozenne, Sara Kristiansen, Daniel Burmester, David Erritzoe, Gitte Moos Knudsen, and Patrick MacDonald Fisher. “Brain Serotonin 2A Receptor Binding Predicts Subjective Temporal and Mystical Effects of Psilocybin in Healthy Humans.” ''Journal of Psychopharmacology'' 35, no. 4 (April 1, 2021): 459–68. <nowiki>https://doi.org/10.1177/0269881120959609</nowiki>.</ref></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Psilocybin effects of psilocybin are mediated/reflected in the agonism of the serotonin 2A receptor (5-HT2AR)<ins style="font-weight: bold; text-decoration: none;">, as measured via PET scans.<ref>Stenbæk, Dea Siggaard, Martin Korsbak Madsen, Brice Ozenne, Sara Kristiansen, Daniel Burmester, David Erritzoe, Gitte Moos Knudsen, and Patrick MacDonald Fisher. “Brain Serotonin 2A Receptor Binding Predicts Subjective Temporal and Mystical Effects of Psilocybin in Healthy Humans.” ''Journal of Psychopharmacology'' 35, no. 4 (April 1, 2021): 459–68. <nowiki>https://doi.org/10.1177/0269881120959609</nowiki>.</ref> Note, given the difficulty of obtaining large PET scans, there is a high correlation between plasma psilocin and 5-HT2AR occupancy, plasma psilocin levels may be used as an accurate surrogate</ins>.<ref>Stenbæk, Dea Siggaard, Martin Korsbak Madsen, Brice Ozenne, Sara Kristiansen, Daniel Burmester, David Erritzoe, Gitte Moos Knudsen, and Patrick MacDonald Fisher. “Brain Serotonin 2A Receptor Binding Predicts Subjective Temporal and Mystical Effects of Psilocybin in Healthy Humans.” ''Journal of Psychopharmacology'' 35, no. 4 (April 1, 2021): 459–68. <nowiki>https://doi.org/10.1177/0269881120959609</nowiki>.</ref> </div></td></tr>
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Michael