https://spiritwiki.lightningpath.org/index.php?action=history&feed=atom&title=LSD
LSD - Revision history
2026-06-28T11:52:27Z
Revision history for this page on the wiki
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https://spiritwiki.lightningpath.org/index.php?title=LSD&diff=25220&oldid=prev
Tristan at 17:25, 20 January 2023
2023-01-20T17:25:09Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 17:25, 20 January 2023</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>"LSD produced long-lasting and notable reductions in anxiety and comorbid depression symptoms up to 16 weeks." <ref>Friederike Holze et al., “Lysergic Acid Diethylamide–Assisted Therapy in Patients With Anxiety With and Without a Life-Threatening Illness: A Randomized, Double-Blind, Placebo-Controlled Phase II Study,” ''Biological Psychiatry'' 93, no. 3 (February 1, 2023): 215–23, <nowiki>https://doi.org/10.1016/j.biopsych.2022.08.025</nowiki>.</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>"LSD produced long-lasting and notable reductions in anxiety and comorbid depression symptoms up to 16 weeks." <ref>Friederike Holze et al., “Lysergic Acid Diethylamide–Assisted Therapy in Patients With Anxiety With and Without a Life-Threatening Illness: A Randomized, Double-Blind, Placebo-Controlled Phase II Study,” ''Biological Psychiatry'' 93, no. 3 (February 1, 2023): 215–23, <nowiki>https://doi.org/10.1016/j.biopsych.2022.08.025</nowiki>.</ref></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">"two high doses of LSD in patients with a life‐threatening illness resulted in reductions in anxiety for up to 2 months." Researchers concluded that the LSD treatments resulted in rapid improvement in depressive symptoms and highlighted uses for LSD in long-term treatment for anxiety. <ref>“LSD Reduces Anxiety Symptoms in Phase 2 Trial.,” ''Brown University Psychopharmacology Update'' 34, no. 1 (January 2023): 2, <nowiki>https://doi.org/10.1002/pu.30965</nowiki>.</ref></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Glazer et al. attributed to low doses of LSD and their positive effects on the reward processing centers of the brain. Suggests that low doses of LSD may be important for treating depression. "The current study examined the effects of single, low doses of LSD (13 and 26 μg) versus placebo (LSD-0) on neural activity during reward processing in healthy adults. Compared to LSD-0, LSD-13 enhanced the hedonic and affective impact of reward (vs. neutral) feedback, reflected by increased RewP and LPP amplitudes, while both LSD-13 and LSD-26 increased the motivational salience of positive (vs. negative) feedback, reflected by increased FB-P3 amplitudes. Of note, these doses produce subjective effects that are comparable to low doses of amphetamine [50], including increases in energy, positive mood, elation, anxiety, and intellectual efficiency [12]. The ERP amplitudes in the current study were unrelated to most of these subjective effects (see Supplementary Materials). These results suggest single, low doses of LSD broadly increased neural sensitivity to reward feedback, particularly at doses that produce few perceptible subjective effects. If these findings extend to repeated doses in symptomatic participants, they may have important implications for the treatment of depressive disorders." <ref>James Glazer et al., “Low Doses of Lysergic Acid Diethylamide (LSD) Increase Reward-Related Brain Activity,” ''Neuropsychopharmacology'' 48, no. 2 (January 1, 2023): 418–26, <nowiki>https://doi.org/10.1038/s41386-022-01479-y</nowiki>.</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Glazer et al. attributed to low doses of LSD and their positive effects on the reward processing centers of the brain. Suggests that low doses of LSD may be important for treating depression. "The current study examined the effects of single, low doses of LSD (13 and 26 μg) versus placebo (LSD-0) on neural activity during reward processing in healthy adults. Compared to LSD-0, LSD-13 enhanced the hedonic and affective impact of reward (vs. neutral) feedback, reflected by increased RewP and LPP amplitudes, while both LSD-13 and LSD-26 increased the motivational salience of positive (vs. negative) feedback, reflected by increased FB-P3 amplitudes. Of note, these doses produce subjective effects that are comparable to low doses of amphetamine [50], including increases in energy, positive mood, elation, anxiety, and intellectual efficiency [12]. The ERP amplitudes in the current study were unrelated to most of these subjective effects (see Supplementary Materials). These results suggest single, low doses of LSD broadly increased neural sensitivity to reward feedback, particularly at doses that produce few perceptible subjective effects. If these findings extend to repeated doses in symptomatic participants, they may have important implications for the treatment of depressive disorders." <ref>James Glazer et al., “Low Doses of Lysergic Acid Diethylamide (LSD) Increase Reward-Related Brain Activity,” ''Neuropsychopharmacology'' 48, no. 2 (January 1, 2023): 418–26, <nowiki>https://doi.org/10.1038/s41386-022-01479-y</nowiki>.</ref></div></td></tr>
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Tristan
https://spiritwiki.lightningpath.org/index.php?title=LSD&diff=25196&oldid=prev
Tristan: /* Notes */
2023-01-15T18:34:57Z
<p><span class="autocomment">Notes</span></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 18:34, 15 January 2023</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Low doses of LSD (20ug) significantly increased the time subjects were able to withstand cold temperature. The dose also reduced the subjects subjective levels of pain and unpleasantness. <ref>Johannes G Ramaekers et al., “A Low Dose of Lysergic Acid Diethylamide Decreases Pain Perception in Healthy Volunteers,” ''Journal of Psychopharmacology'' 35, no. 4 (April 1, 2021): 398–405, <nowiki>https://doi.org/10.1177/0269881120940937</nowiki>.</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Low doses of LSD (20ug) significantly increased the time subjects were able to withstand cold temperature. The dose also reduced the subjects subjective levels of pain and unpleasantness. <ref>Johannes G Ramaekers et al., “A Low Dose of Lysergic Acid Diethylamide Decreases Pain Perception in Healthy Volunteers,” ''Journal of Psychopharmacology'' 35, no. 4 (April 1, 2021): 398–405, <nowiki>https://doi.org/10.1177/0269881120940937</nowiki>.</ref></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">LSD increases the effect (wonderment, awe, power, transcendence, feeling, etc) of music on an individual. <ref>Mendel Kaelen et al., “The Hidden Therapist: Evidence for a Central Role of Music Inpsychedelic Therapy,” ''Psychopharmacology'' 235, no. 2 (February 1, 2018): 505–19, <nowiki>https://doi.org/10.1007/s00213-017-4820-5</nowiki>.</ref> <ref>M. Kaelen et al., “LSD Enhances the Emotional Response to Music,” ''Psychopharmacology'' 232, no. 19 (October 1, 2015): 3607–14, <nowiki>https://doi.org/10.1007/s00213-015-4014-y</nowiki>.</ref> <ref>Frederick Barrett, Katrin Preller, and Mendel Kaelen, “Psychedelics and Music: Neuroscience and Therapeutic Implications,” ''International Review of Psychiatry'' 30 (September 21, 2018): 1–13, <nowiki>https://doi.org/10.1080/09540261.2018.1484342</nowiki>.</ref></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Enhancements==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Enhancements==</div></td></tr>
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Tristan
https://spiritwiki.lightningpath.org/index.php?title=LSD&diff=25120&oldid=prev
Tristan: /* Notes */
2023-01-13T18:58:42Z
<p><span class="autocomment">Notes</span></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 18:58, 13 January 2023</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Lifetime use of LSD, MDMA, and Psilocybin mushrooms is associated with significantly lower rates of major depressive episodes (MDEs). Jones et al. finds that Psilocybin is associated with reduced past-year MDEs whereas LSD/MDMA are associated with a global reduction in MDEs. <ref>Grant M. Jones and Matthew K. Nock, “Lifetime Use of MDMA/Ecstasy and Psilocybin Is Associated with Reduced Odds of Major Depressive Episodes,” ''Journal of Psychopharmacology'' 36, no. 1 (January 2022): 57–65, <nowiki>https://doi.org/10.1177/02698811211066714</nowiki>.</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Lifetime use of LSD, MDMA, and Psilocybin mushrooms is associated with significantly lower rates of major depressive episodes (MDEs). Jones et al. finds that Psilocybin is associated with reduced past-year MDEs whereas LSD/MDMA are associated with a global reduction in MDEs. <ref>Grant M. Jones and Matthew K. Nock, “Lifetime Use of MDMA/Ecstasy and Psilocybin Is Associated with Reduced Odds of Major Depressive Episodes,” ''Journal of Psychopharmacology'' 36, no. 1 (January 2022): 57–65, <nowiki>https://doi.org/10.1177/02698811211066714</nowiki>.</ref></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">"LSD produced long-lasting and notable reductions in anxiety and comorbid depression symptoms up to 16 weeks." <ref>Friederike Holze et al., “Lysergic Acid Diethylamide–Assisted Therapy in Patients With Anxiety With and Without a Life-Threatening Illness: A Randomized, Double-Blind, Placebo-Controlled Phase II Study,” ''Biological Psychiatry'' 93, no. 3 (February 1, 2023): 215–23, <nowiki>https://doi.org/10.1016/j.biopsych.2022.08.025</nowiki>.</ref></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Glazer et al. attributed to low doses of LSD and their positive effects on the reward processing centers of the brain. Suggests that low doses of LSD may be important for treating depression. "The current study examined the effects of single, low doses of LSD (13 and 26 μg) versus placebo (LSD-0) on neural activity during reward processing in healthy adults. Compared to LSD-0, LSD-13 enhanced the hedonic and affective impact of reward (vs. neutral) feedback, reflected by increased RewP and LPP amplitudes, while both LSD-13 and LSD-26 increased the motivational salience of positive (vs. negative) feedback, reflected by increased FB-P3 amplitudes. Of note, these doses produce subjective effects that are comparable to low doses of amphetamine [50], including increases in energy, positive mood, elation, anxiety, and intellectual efficiency [12]. The ERP amplitudes in the current study were unrelated to most of these subjective effects (see Supplementary Materials). These results suggest single, low doses of LSD broadly increased neural sensitivity to reward feedback, particularly at doses that produce few perceptible subjective effects. If these findings extend to repeated doses in symptomatic participants, they may have important implications for the treatment of depressive disorders." <ref>James Glazer et al., “Low Doses of Lysergic Acid Diethylamide (LSD) Increase Reward-Related Brain Activity,” ''Neuropsychopharmacology'' 48, no. 2 (January 1, 2023): 418–26, <nowiki>https://doi.org/10.1038/s41386-022-01479-y</nowiki>.</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Glazer et al. attributed to low doses of LSD and their positive effects on the reward processing centers of the brain. Suggests that low doses of LSD may be important for treating depression. "The current study examined the effects of single, low doses of LSD (13 and 26 μg) versus placebo (LSD-0) on neural activity during reward processing in healthy adults. Compared to LSD-0, LSD-13 enhanced the hedonic and affective impact of reward (vs. neutral) feedback, reflected by increased RewP and LPP amplitudes, while both LSD-13 and LSD-26 increased the motivational salience of positive (vs. negative) feedback, reflected by increased FB-P3 amplitudes. Of note, these doses produce subjective effects that are comparable to low doses of amphetamine [50], including increases in energy, positive mood, elation, anxiety, and intellectual efficiency [12]. The ERP amplitudes in the current study were unrelated to most of these subjective effects (see Supplementary Materials). These results suggest single, low doses of LSD broadly increased neural sensitivity to reward feedback, particularly at doses that produce few perceptible subjective effects. If these findings extend to repeated doses in symptomatic participants, they may have important implications for the treatment of depressive disorders." <ref>James Glazer et al., “Low Doses of Lysergic Acid Diethylamide (LSD) Increase Reward-Related Brain Activity,” ''Neuropsychopharmacology'' 48, no. 2 (January 1, 2023): 418–26, <nowiki>https://doi.org/10.1038/s41386-022-01479-y</nowiki>.</ref></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>"It has been proposed that classical psychedelics produce therapeutic effects by altering spontaneous cortical activity, inducing neural entropy that counters maladaptive neuroplasticity and associated mental rigidity" <ref>Conor H. Murray et al., “Low Doses of LSD Reduce Broadband Oscillatory Power and Modulate Event-Related Potentials in Healthy Adults.,” ''Psychopharmacology'' 239, no. 6 (June 2022): 1735–47.</ref> This action noted and discuss by Carhart-Harris and Friston. <ref>R. L. Carhart-Harris and K. J. Friston, “REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics,” ed. Eric L. Barker, ''Pharmacological Reviews'' 71, no. 3 (July 1, 2019): 316, <nowiki>https://doi.org/10.1124/pr.118.017160</nowiki>.</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>"It has been proposed that classical psychedelics produce therapeutic effects by altering spontaneous cortical activity, inducing neural entropy that counters maladaptive neuroplasticity and associated mental rigidity" <ref>Conor H. Murray et al., “Low Doses of LSD Reduce Broadband Oscillatory Power and Modulate Event-Related Potentials in Healthy Adults.,” ''Psychopharmacology'' 239, no. 6 (June 2022): 1735–47.</ref> This action noted and discuss by Carhart-Harris and Friston. <ref>R. L. Carhart-Harris and K. J. Friston, “REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics,” ed. Eric L. Barker, ''Pharmacological Reviews'' 71, no. 3 (July 1, 2019): 316, <nowiki>https://doi.org/10.1124/pr.118.017160</nowiki>.</ref></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Low doses of LSD (20ug) significantly increased the time subjects were able to withstand cold temperature. The dose also reduced the subjects subjective levels of pain and unpleasantness. <ref>Johannes G Ramaekers et al., “A Low Dose of Lysergic Acid Diethylamide Decreases Pain Perception in Healthy Volunteers,” ''Journal of Psychopharmacology'' 35, no. 4 (April 1, 2021): 398–405, <nowiki>https://doi.org/10.1177/0269881120940937</nowiki>.</ref></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Enhancements==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Enhancements==</div></td></tr>
</table>
Tristan
https://spiritwiki.lightningpath.org/index.php?title=LSD&diff=25114&oldid=prev
Tristan at 18:43, 11 January 2023
2023-01-11T18:43:03Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 18:43, 11 January 2023</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Low doses of LSD (13ug-26ug) have the same positive emotional and cognitive impacts as base-standard doses of LSD (75ug). Study shows EEG effects are similar with both ranges of doses. <ref>Conor H. Murray et al., “Low Doses of LSD Reduce Broadband Oscillatory Power and Modulate Event-Related Potentials in Healthy Adults.,” ''Psychopharmacology'' 239, no. 6 (June 2022): 1735–47.</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Low doses of LSD (13ug-26ug) have the same positive emotional and cognitive impacts as base-standard doses of LSD (75ug). Study shows EEG effects are similar with both ranges of doses. <ref>Conor H. Murray et al., “Low Doses of LSD Reduce Broadband Oscillatory Power and Modulate Event-Related Potentials in Healthy Adults.,” ''Psychopharmacology'' 239, no. 6 (June 2022): 1735–47.</ref></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">As Wießner et al shows, low doses of LSD moderately induced the "afterglow" effect in test subjects. However, the researcher concludes that improvements to visuospatial memory and phonological fluency suggest that LSD-assisted therapies can be explored as novel-treatments for brain injuries, strokes, and language decline. <ref>Isabel Wießner et al., “LSD, Afterglow and Hangover: Increased Episodic Memory and Verbal Fluency, Decreased Cognitive Flexibility,” ''European Neuropsychopharmacology'' 58 (May 1, 2022): 7–19.</ref></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Lifetime use of LSD, MDMA, and Psilocybin mushrooms is associated with significantly lower rates of major depressive episodes (MDEs). Jones et al. finds that Psilocybin is associated with reduced past-year MDEs whereas LSD/MDMA are associated with a global reduction in MDEs. <ref>Grant M. Jones and Matthew K. Nock, “Lifetime Use of MDMA/Ecstasy and Psilocybin Is Associated with Reduced Odds of Major Depressive Episodes,” ''Journal of Psychopharmacology'' 36, no. 1 (January 2022): 57–65, <nowiki>https://doi.org/10.1177/02698811211066714</nowiki>.</ref></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Glazer et al. attributed to low doses of LSD and their positive effects on the reward processing centers of the brain. Suggests that low doses of LSD may be important for treating depression. "The current study examined the effects of single, low doses of LSD (13 and 26 μg) versus placebo (LSD-0) on neural activity during reward processing in healthy adults. Compared to LSD-0, LSD-13 enhanced the hedonic and affective impact of reward (vs. neutral) feedback, reflected by increased RewP and LPP amplitudes, while both LSD-13 and LSD-26 increased the motivational salience of positive (vs. negative) feedback, reflected by increased FB-P3 amplitudes. Of note, these doses produce subjective effects that are comparable to low doses of amphetamine [50], including increases in energy, positive mood, elation, anxiety, and intellectual efficiency [12]. The ERP amplitudes in the current study were unrelated to most of these subjective effects (see Supplementary Materials). These results suggest single, low doses of LSD broadly increased neural sensitivity to reward feedback, particularly at doses that produce few perceptible subjective effects. If these findings extend to repeated doses in symptomatic participants, they may have important implications for the treatment of depressive disorders." <ref>James Glazer et al., “Low Doses of Lysergic Acid Diethylamide (LSD) Increase Reward-Related Brain Activity,” ''Neuropsychopharmacology'' 48, no. 2 (January 1, 2023): 418–26, <nowiki>https://doi.org/10.1038/s41386-022-01479-y</nowiki>.</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Glazer et al. attributed to low doses of LSD and their positive effects on the reward processing centers of the brain. Suggests that low doses of LSD may be important for treating depression. "The current study examined the effects of single, low doses of LSD (13 and 26 μg) versus placebo (LSD-0) on neural activity during reward processing in healthy adults. Compared to LSD-0, LSD-13 enhanced the hedonic and affective impact of reward (vs. neutral) feedback, reflected by increased RewP and LPP amplitudes, while both LSD-13 and LSD-26 increased the motivational salience of positive (vs. negative) feedback, reflected by increased FB-P3 amplitudes. Of note, these doses produce subjective effects that are comparable to low doses of amphetamine [50], including increases in energy, positive mood, elation, anxiety, and intellectual efficiency [12]. The ERP amplitudes in the current study were unrelated to most of these subjective effects (see Supplementary Materials). These results suggest single, low doses of LSD broadly increased neural sensitivity to reward feedback, particularly at doses that produce few perceptible subjective effects. If these findings extend to repeated doses in symptomatic participants, they may have important implications for the treatment of depressive disorders." <ref>James Glazer et al., “Low Doses of Lysergic Acid Diethylamide (LSD) Increase Reward-Related Brain Activity,” ''Neuropsychopharmacology'' 48, no. 2 (January 1, 2023): 418–26, <nowiki>https://doi.org/10.1038/s41386-022-01479-y</nowiki>.</ref></div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>LSD has nootropic properties.<ref>Dolan, Eric W. “Neuroscience Research Suggests LSD Might Enhance Learning and Memory by Promoting Brain Plasticity.” PsyPost, August 11, 2022. <nowiki>https://www.psypost.org/2022/08/neuroscience-research-suggests-lsd-might-enhance-learning-and-memory-by-promoting-brain-plasticity-63701</nowiki>.</ref> LSD " LSD increased markers of neuroplasticity in human brain organoids, increased novelty preference in rats, and improved memory performance in humans." For the scholarly article behind the news articles, [https://www.sciencedirect.com/science/article/abs/pii/S001448862200173X see this link].<ref>Ornelas, Isis M., Felipe A. Cini, Isabel Wießner, Encarni Marcos, Dráulio B. Araújo, Livia Goto-Silva, Juliana Nascimento, et al. “Nootropic Effects of LSD: Behavioral, Molecular and Computational Evidence.” ''Experimental Neurology'' 356 (October 1, 2022): 114148. <nowiki>https://doi.org/10.1016/j.expneurol.2022.114148</nowiki>.</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>LSD has nootropic properties.<ref>Dolan, Eric W. “Neuroscience Research Suggests LSD Might Enhance Learning and Memory by Promoting Brain Plasticity.” PsyPost, August 11, 2022. <nowiki>https://www.psypost.org/2022/08/neuroscience-research-suggests-lsd-might-enhance-learning-and-memory-by-promoting-brain-plasticity-63701</nowiki>.</ref> LSD " LSD increased markers of neuroplasticity in human brain organoids, increased novelty preference in rats, and improved memory performance in humans." For the scholarly article behind the news articles, [https://www.sciencedirect.com/science/article/abs/pii/S001448862200173X see this link].<ref>Ornelas, Isis M., Felipe A. Cini, Isabel Wießner, Encarni Marcos, Dráulio B. Araújo, Livia Goto-Silva, Juliana Nascimento, et al. “Nootropic Effects of LSD: Behavioral, Molecular and Computational Evidence.” ''Experimental Neurology'' 356 (October 1, 2022): 114148. <nowiki>https://doi.org/10.1016/j.expneurol.2022.114148</nowiki>.</ref></div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">In conclusion, the low dose of LSD moderately induced both “afterglow” and “hangover”. The improvements in visuospatial memory and phonological fluency suggest that LSD-assisted therapy should be explored as a novel treatment perspective in conditions involving memory and language declines such as brain injury, stroke or dementia.</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">As Wießner et al shows, low doses of LSD moderately induced the "afterglow" effect in test subjects. However, the researcher concludes that improvements to visuospatial memory and phonological fluency suggest that LSD-assisted therapies can be explored as novel-treatments for brain injuries, strokes, and language decline. <ref>Isabel Wießner et al., “LSD, Afterglow and Hangover: Increased Episodic Memory and Verbal Fluency, Decreased Cognitive Flexibility,” ''European Neuropsychopharmacology'' 58 (May 1, 2022): 7–19.</ref></del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>LSD makes the mouse more social.<ref>Inserra, Antonio, Giada Giorgini, Sebastien Lacroix, Antonella Bertazzo, Jocelyn Choo, Athanasios Markopolous, Emily Grant, et al. “Effects of Repeated Lysergic Acid Diethylamide (LSD) on the Mouse Brain Endocannabinoidome and Gut Microbiome.” ''British Journal of Pharmacology'', October 31, 2022. https://doi.org/10.1111/bph.15977</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>LSD makes the mouse more social.<ref>Inserra, Antonio, Giada Giorgini, Sebastien Lacroix, Antonella Bertazzo, Jocelyn Choo, Athanasios Markopolous, Emily Grant, et al. “Effects of Repeated Lysergic Acid Diethylamide (LSD) on the Mouse Brain Endocannabinoidome and Gut Microbiome.” ''British Journal of Pharmacology'', October 31, 2022. https://doi.org/10.1111/bph.15977</ref></div></td></tr>
</table>
Tristan
https://spiritwiki.lightningpath.org/index.php?title=LSD&diff=25113&oldid=prev
Tristan: /* Notes */
2023-01-11T06:10:19Z
<p><span class="autocomment">Notes</span></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 06:10, 11 January 2023</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>LSD has nootropic properties.<ref>Dolan, Eric W. “Neuroscience Research Suggests LSD Might Enhance Learning and Memory by Promoting Brain Plasticity.” PsyPost, August 11, 2022. <nowiki>https://www.psypost.org/2022/08/neuroscience-research-suggests-lsd-might-enhance-learning-and-memory-by-promoting-brain-plasticity-63701</nowiki>.</ref> LSD " LSD increased markers of neuroplasticity in human brain organoids, increased novelty preference in rats, and improved memory performance in humans." For the scholarly article behind the news articles, [https://www.sciencedirect.com/science/article/abs/pii/S001448862200173X see this link].<ref>Ornelas, Isis M., Felipe A. Cini, Isabel Wießner, Encarni Marcos, Dráulio B. Araújo, Livia Goto-Silva, Juliana Nascimento, et al. “Nootropic Effects of LSD: Behavioral, Molecular and Computational Evidence.” ''Experimental Neurology'' 356 (October 1, 2022): 114148. <nowiki>https://doi.org/10.1016/j.expneurol.2022.114148</nowiki>.</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>LSD has nootropic properties.<ref>Dolan, Eric W. “Neuroscience Research Suggests LSD Might Enhance Learning and Memory by Promoting Brain Plasticity.” PsyPost, August 11, 2022. <nowiki>https://www.psypost.org/2022/08/neuroscience-research-suggests-lsd-might-enhance-learning-and-memory-by-promoting-brain-plasticity-63701</nowiki>.</ref> LSD " LSD increased markers of neuroplasticity in human brain organoids, increased novelty preference in rats, and improved memory performance in humans." For the scholarly article behind the news articles, [https://www.sciencedirect.com/science/article/abs/pii/S001448862200173X see this link].<ref>Ornelas, Isis M., Felipe A. Cini, Isabel Wießner, Encarni Marcos, Dráulio B. Araújo, Livia Goto-Silva, Juliana Nascimento, et al. “Nootropic Effects of LSD: Behavioral, Molecular and Computational Evidence.” ''Experimental Neurology'' 356 (October 1, 2022): 114148. <nowiki>https://doi.org/10.1016/j.expneurol.2022.114148</nowiki>.</ref></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">In conclusion, the low dose of LSD moderately induced both “afterglow” and “hangover”. The improvements in visuospatial memory and phonological fluency suggest that LSD-assisted therapy should be explored as a novel treatment perspective in conditions involving memory and language declines such as brain injury, stroke or dementia.</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">As Wießner et al shows, low doses of LSD moderately induced the "afterglow" effect in test subjects. However, the researcher concludes that improvements to visuospatial memory and phonological fluency suggest that LSD-assisted therapies can be explored as novel-treatments for brain injuries, strokes, and language decline. <ref>Isabel Wießner et al., “LSD, Afterglow and Hangover: Increased Episodic Memory and Verbal Fluency, Decreased Cognitive Flexibility,” ''European Neuropsychopharmacology'' 58 (May 1, 2022): 7–19.</ref></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>LSD makes the mouse more social.<ref>Inserra, Antonio, Giada Giorgini, Sebastien Lacroix, Antonella Bertazzo, Jocelyn Choo, Athanasios Markopolous, Emily Grant, et al. “Effects of Repeated Lysergic Acid Diethylamide (LSD) on the Mouse Brain Endocannabinoidome and Gut Microbiome.” ''British Journal of Pharmacology'', October 31, 2022. https://doi.org/10.1111/bph.15977</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>LSD makes the mouse more social.<ref>Inserra, Antonio, Giada Giorgini, Sebastien Lacroix, Antonella Bertazzo, Jocelyn Choo, Athanasios Markopolous, Emily Grant, et al. “Effects of Repeated Lysergic Acid Diethylamide (LSD) on the Mouse Brain Endocannabinoidome and Gut Microbiome.” ''British Journal of Pharmacology'', October 31, 2022. https://doi.org/10.1111/bph.15977</ref></div></td></tr>
</table>
Tristan
https://spiritwiki.lightningpath.org/index.php?title=LSD&diff=24845&oldid=prev
Tristan: /* Notes */
2023-01-01T18:45:54Z
<p><span class="autocomment">Notes</span></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 18:45, 1 January 2023</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Low doses of LSD (13ug-26ug) have the same positive emotional and cognitive impacts as base-standard doses of LSD (75ug). Study shows EEG effects are similar with both ranges of doses. <ref>Conor H. Murray et al., “Low Doses of LSD Reduce Broadband Oscillatory Power and Modulate Event-Related Potentials in Healthy Adults.,” ''Psychopharmacology'' 239, no. 6 (June 2022): 1735–47.</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Low doses of LSD (13ug-26ug) have the same positive emotional and cognitive impacts as base-standard doses of LSD (75ug). Study shows EEG effects are similar with both ranges of doses. <ref>Conor H. Murray et al., “Low Doses of LSD Reduce Broadband Oscillatory Power and Modulate Event-Related Potentials in Healthy Adults.,” ''Psychopharmacology'' 239, no. 6 (June 2022): 1735–47.</ref></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Glazer et al. attributed to low doses of LSD and their positive effects on the reward processing centers of the brain. Suggests that low doses of LSD may be important for treating depression. "The current study examined the effects of single, low doses of LSD (13 and 26 μg) versus placebo (LSD-0) on neural activity during reward processing in healthy adults. Compared to LSD-0, LSD-13 enhanced the hedonic and affective impact of reward (vs. neutral) feedback, reflected by increased RewP and LPP amplitudes, while both LSD-13 and LSD-26 increased the motivational salience of positive (vs. negative) feedback, reflected by increased FB-P3 amplitudes. Of note, these doses produce subjective effects that are comparable to low doses of amphetamine [50], including increases in energy, positive mood, elation, anxiety, and intellectual efficiency [12]. The ERP amplitudes in the current study were unrelated to most of these subjective effects (see Supplementary Materials). These results suggest single, low doses of LSD broadly increased neural sensitivity to reward feedback, particularly at doses that produce few perceptible subjective effects. If these findings extend to repeated doses in symptomatic participants, they may have important implications for the treatment of depressive disorders." <ref>James Glazer et al., “Low Doses of Lysergic Acid Diethylamide (LSD) Increase Reward-Related Brain Activity,” ''Neuropsychopharmacology'' 48, no. 2 (January 1, 2023): 418–26, <nowiki>https://doi.org/10.1038/s41386-022-01479-y</nowiki>.</ref></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>"It has been proposed that classical psychedelics produce therapeutic effects by altering spontaneous cortical activity, inducing neural entropy that counters maladaptive neuroplasticity and associated mental rigidity" <ref>Conor H. Murray et al., “Low Doses of LSD Reduce Broadband Oscillatory Power and Modulate Event-Related Potentials in Healthy Adults.,” ''Psychopharmacology'' 239, no. 6 (June 2022): 1735–47.</ref> This action noted and discuss by Carhart-Harris and Friston. <ref>R. L. Carhart-Harris and K. J. Friston, “REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics,” ed. Eric L. Barker, ''Pharmacological Reviews'' 71, no. 3 (July 1, 2019): 316, <nowiki>https://doi.org/10.1124/pr.118.017160</nowiki>.</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>"It has been proposed that classical psychedelics produce therapeutic effects by altering spontaneous cortical activity, inducing neural entropy that counters maladaptive neuroplasticity and associated mental rigidity" <ref>Conor H. Murray et al., “Low Doses of LSD Reduce Broadband Oscillatory Power and Modulate Event-Related Potentials in Healthy Adults.,” ''Psychopharmacology'' 239, no. 6 (June 2022): 1735–47.</ref> This action noted and discuss by Carhart-Harris and Friston. <ref>R. L. Carhart-Harris and K. J. Friston, “REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics,” ed. Eric L. Barker, ''Pharmacological Reviews'' 71, no. 3 (July 1, 2019): 316, <nowiki>https://doi.org/10.1124/pr.118.017160</nowiki>.</ref></div></td></tr>
</table>
Tristan
https://spiritwiki.lightningpath.org/index.php?title=LSD&diff=24831&oldid=prev
Tristan at 18:18, 30 December 2022
2022-12-30T18:18:19Z
<p></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 18:18, 30 December 2022</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l21">Line 21:</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Low doses of LSD (13ug-26ug) have the same positive emotional and cognitive impacts as base-standard doses of LSD (75ug). Study shows EEG effects are similar with both ranges of doses. <ref>Conor H. Murray et al., “Low Doses of LSD Reduce Broadband Oscillatory Power and Modulate Event-Related Potentials in Healthy Adults.,” ''Psychopharmacology'' 239, no. 6 (June 2022): 1735–47.</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Low doses of LSD (13ug-26ug) have the same positive emotional and cognitive impacts as base-standard doses of LSD (75ug). Study shows EEG effects are similar with both ranges of doses. <ref>Conor H. Murray et al., “Low Doses of LSD Reduce Broadband Oscillatory Power and Modulate Event-Related Potentials in Healthy Adults.,” ''Psychopharmacology'' 239, no. 6 (June 2022): 1735–47.</ref></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>"It has been proposed that classical psychedelics produce therapeutic effects by altering spontaneous cortical activity, inducing neural entropy that counters maladaptive neuroplasticity and associated mental rigidity" <ref>Conor H. Murray et al., “Low Doses of LSD Reduce Broadband Oscillatory Power and Modulate Event-Related Potentials in Healthy Adults.,” ''Psychopharmacology'' 239, no. 6 (June 2022): 1735–47.</ref></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>"It has been proposed that classical psychedelics produce therapeutic effects by altering spontaneous cortical activity, inducing neural entropy that counters maladaptive neuroplasticity and associated mental rigidity" <ref>Conor H. Murray et al., “Low Doses of LSD Reduce Broadband Oscillatory Power and Modulate Event-Related Potentials in Healthy Adults.,” ''Psychopharmacology'' 239, no. 6 (June 2022): 1735–47<ins style="font-weight: bold; text-decoration: none;">.</ref> This action noted and discuss by Carhart-Harris and Friston. <ref>R. L. Carhart-Harris and K. J. Friston, “REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics,” ed. Eric L. Barker, ''Pharmacological Reviews'' 71, no. 3 (July 1, 2019): 316, <nowiki>https://doi.org/10.1124/pr.118.017160</nowiki></ins>.</ref></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Enhancements==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Enhancements==</div></td></tr>
</table>
Tristan
https://spiritwiki.lightningpath.org/index.php?title=LSD&diff=24830&oldid=prev
Tristan at 18:14, 30 December 2022
2022-12-30T18:14:20Z
<p></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 18:14, 30 December 2022</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Notes==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Notes==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Statistics show overall LSD and psychedelic use has increased from the years 2002-2019. <ref>Ofir Livne et al., “Adolescent and Adult Time Trends in US Hallucinogen Use, 2002–19: Any Use, and Use of Ecstasy, LSD and PCP.,” ''Addiction'' 117, no. 12 (December 2022): 3099–3109.</ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Statistics show overall LSD and psychedelic use has increased from the years 2002-2019. <ref>Ofir Livne et al., “Adolescent and Adult Time Trends in US Hallucinogen Use, 2002–19: Any Use, and Use of Ecstasy, LSD and PCP.,” ''Addiction'' 117, no. 12 (December 2022): 3099–3109.</ref></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Low doses of LSD (13ug-26ug) have the same positive emotional and cognitive impacts as base-standard doses of LSD (75ug). Study shows EEG effects are similar with both ranges of doses. <ref>Conor H. Murray et al., “Low Doses of LSD Reduce Broadband Oscillatory Power and Modulate Event-Related Potentials in Healthy Adults.,” ''Psychopharmacology'' 239, no. 6 (June 2022): 1735–47.</ref></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">"It has been proposed that classical psychedelics produce therapeutic effects by altering spontaneous cortical activity, inducing neural entropy that counters maladaptive neuroplasticity and associated mental rigidity" <ref>Conor H. Murray et al., “Low Doses of LSD Reduce Broadband Oscillatory Power and Modulate Event-Related Potentials in Healthy Adults.,” ''Psychopharmacology'' 239, no. 6 (June 2022): 1735–47.</ref></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Enhancements==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Enhancements==</div></td></tr>
</table>
Tristan
https://spiritwiki.lightningpath.org/index.php?title=LSD&diff=24829&oldid=prev
Tristan: /* Notes */
2022-12-30T18:00:04Z
<p><span class="autocomment">Notes</span></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 18:00, 30 December 2022</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Connection Supplement]] > {{#ask:[[Is a related term::Connection Supplement]]}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Connection Supplement]] > {{#ask:[[Is a related term::Connection Supplement]]}}</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Notes==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Notes==</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Statistics show overall LSD and psychedelic use has increased from the years 2002-2019. <ref>Ofir Livne et al., “Adolescent and Adult Time Trends in US Hallucinogen Use, 2002–19: Any Use, and Use of Ecstasy, LSD and PCP.,” ''Addiction'' 117, no. 12 (December 2022): 3099–3109.</ref></ins></div></td></tr>
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Tristan
https://spiritwiki.lightningpath.org/index.php?title=LSD&diff=24828&oldid=prev
Tristan at 17:55, 30 December 2022
2022-12-30T17:55:36Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 17:55, 30 December 2022</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Connection Supplement]] > {{#ask:[[Is a related term::Connection Supplement]]}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Connection Supplement]] > {{#ask:[[Is a related term::Connection Supplement]]}}</div></td></tr>
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Tristan